Goal: After biopsy, integrate MRI findings, biopsy pathology whole-slide images, and PSA-related variables to determine whether the patient is eligible for active surveillance or should proceed to radical prostatectomy, with guideline-based reasoning (EAU/NCCN).
Input modalities
- Multiparametric MRI
- Biopsy H&E whole-slide images (
.tif) - Clinical variables: PSA, age, Gleason Grade Group, biopsy burden
Output required
- Binary recommendation: eligible / not eligible for active surveillance
- Structured reasoning identifying dominant evidence and explicitly flagging factors that contradict active surveillance
Ground truth: Derived retrospectively from biopsy histopathology and PSA-related clinical variables per EAU/NCCN guidelines.
Dataset
| Split | Cases | Notes |
|---|---|---|
| Training | 75 | Radboudumc; real-world class distribution |
| Validation | 75 | Radboudumc; up to 5 submissions allowed |
| Test | 300 | 100 cases from Karolinska Institute (external); 1 submission allowed |
Input data (precomputed): Precomputed MRI features as .h5 files + precomputed biopsy WSI features as .h5 files + clinical variables as .csv. Raw images are not provided for inference.
Expected output per case: JSON file (~5 KB) containing the active surveillance eligibility decision and structured reasoning trace.
Primary metric: AUROC
Provided tools: Automated Gleason grading tool for biopsy WSI; MRI-based prostate cancer detection tool